SETD1B activates iNOS expression in myeloid-derived suppressor cells

Inducible nitric oxide synthase (iNOS) generates nitric oxide (NO) in myeloid cells that acts as a defense mechanism to suppress invading microorganisms or neoplastic cells. In tumor-bearing mice, elevated iNOS expression is a hallmark of myeloid-derived suppressor cells (MDSC). MDSCs use NO to nitr...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Redd, Priscilla S., Ibrahim, Mohammed L., Klement, John D., Sharman, Sarah K., Paschall, Amy V., Yang, Dafeng, Nayak-Kapoor, Asha, Liu, Kebin
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495112/
https://ncbi.nlm.nih.gov/pubmed/28381543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2238
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