SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth

Trimethylation of histone 3 lysine 9 (H3K9me3) at gene promoters is a major epigenetic mechanism that silences gene expression. We have developed a small molecule inhibitor for the H3K9me3-specific histone methyltransferase SUV39H1. We report here that FAS expression is significantly down-regulated...

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I publikationen:Cancer Lett
Huvudupphovsmän: Lu, Chunwan, Klement, John D., Yang, Dafeng, Albers, Thomas, Lebedyeva, Iryna O., Waller, Jennifer L., Liu, Kebin
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138631/
https://ncbi.nlm.nih.gov/pubmed/32061753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.02.004
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