p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy

BACKGROUND: NF-κB is a key link between inflammation and cancer. Previous studies of NF-κB have largely focused on tumor cells, and the intrinsic function of NF-κB in T cells in tumor development and response to immunotherapy is largely unknown. We aimed at testing the hypothesis that NF-κB1 (p50) a...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Lu, Chunwan, Klement, John D, Smith, Alyssa D, Yang, Dafeng, Waller, Jennifer L, Browning, Darren D, Munn, David H, Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555101/
https://ncbi.nlm.nih.gov/pubmed/33051343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001365
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