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Biocatalytic enantioselective hydroaminations enabling synthesis of N-arylalkyl-substituted l-aspartic acids

N-Substituted l-aspartic acids are important chiral building blocks for pharmaceuticals and food additives. Here we report the asymmetric synthesis of various N-arylalkyl-substituted l-aspartic acids using ethylenediamine-N,N′-disuccinic acid lyase (EDDS lyase) as a biocatalyst. This C–N lyase shows...

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書目詳細資料
發表在:Org Biomol Chem
Main Authors: Abidin, Mohammad Z., Saravanan, Thangavelu, Bothof, Laura, Tepper, Pieter G., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
格式: Artigo
語言:Inglês
出版: The Royal Society of Chemistry 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317194/
https://ncbi.nlm.nih.gov/pubmed/34235532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1ob00748c
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