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The broad amine scope of pantothenate synthetase enables the synthesis of pharmaceutically relevant amides
Pantothenate synthetase from Escherichia coli (PS(E. coli)) catalyzes the ATP-dependent condensation of (R)-pantoic acid and β-alanine to yield (R)-pantothenic acid (vitamin B(5)), the biosynthetic precursor to coenzyme A. Herein we show that besides the natural amine substrate β-alanine, the enzyme...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society of Chemistry
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8150671/ https://ncbi.nlm.nih.gov/pubmed/33913984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1ob00238d |
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