Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

[Image: see text] Chiral γ-aminobutyric acid (GABA) analogues represent abundantly prescribed drugs, which are broadly applied as anticonvulsants, as antidepressants, and for the treatment of neuropathic pain. Here we report a one-pot two-step biocatalytic cascade route for synthesis of the pharmace...

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Publicado en:ACS Catal
Main Authors: Biewenga, Lieuwe, Saravanan, Thangavelu, Kunzendorf, Andreas, van der Meer, Jan-Ytzen, Pijning, Tjaard, Tepper, Pieter G., van Merkerk, Ronald, Charnock, Simon J., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2019
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366683/
https://ncbi.nlm.nih.gov/pubmed/30740262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.8b04299
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