Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

The Michael-type addition reaction is widely used in organic synthesis for carbon–carbon bond formation. However, biocatalytic methodologies for this type of reaction are scarce, which is related to the fact that enzymes naturally catalysing carbon–carbon bond-forming Michael-type additions are rare...

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Publié dans:Nat Commun
Auteurs principaux: van der Meer, Jan-Ytzen, Poddar, Harshwardhan, Baas, Bert-Jan, Miao, Yufeng, Rahimi, Mehran, Kunzendorf, Andreas, van Merkerk, Ronald, Tepper, Pieter G., Geertsema, Edzard M., Thunnissen, Andy-Mark W. H., Quax, Wim J., Poelarends, Gerrit J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786785/
https://ncbi.nlm.nih.gov/pubmed/26952338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10911
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