Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

The Michael-type addition reaction is widely used in organic synthesis for carbon–carbon bond formation. However, biocatalytic methodologies for this type of reaction are scarce, which is related to the fact that enzymes naturally catalysing carbon–carbon bond-forming Michael-type additions are rare...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: van der Meer, Jan-Ytzen, Poddar, Harshwardhan, Baas, Bert-Jan, Miao, Yufeng, Rahimi, Mehran, Kunzendorf, Andreas, van Merkerk, Ronald, Tepper, Pieter G., Geertsema, Edzard M., Thunnissen, Andy-Mark W. H., Quax, Wim J., Poelarends, Gerrit J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786785/
https://ncbi.nlm.nih.gov/pubmed/26952338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10911
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