Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners

Aspartic acid derivatives with branched N‐alkyl or N‐arylalkyl substituents are valuable precursors to artificial dipeptide sweeteners such as neotame and advantame. The development of a biocatalyst to synthesize these compounds in a single asymmetric step is an as yet unmet challenge. Reported here...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Zhang, Jielin, Grandi, Eleonora, Fu, Haigen, Saravanan, Thangavelu, Bothof, Laura, Tepper, Pieter G., Thunnissen, Andy‐Mark W. H., Poelarends, Gerrit J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6973171/
https://ncbi.nlm.nih.gov/pubmed/31625664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201910704
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