Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction

[Image: see text] Although it is well-known that limited local mutations of enzymes, such as matrix metalloproteinases (MMPs), may change enzyme activity by orders of magnitude as well as its stability, the completely rational design of proteins is still challenging. These local changes alter the el...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JACS Au
Prif Awduron: Adams, Ellen M., Pezzotti, Simone, Ahlers, Jonas, Rüttermann, Maximilian, Levin, Maxim, Goldenzweig, Adi, Peleg, Yoav, Fleishman, Sarel J., Sagi, Irit, Havenith, Martina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2021
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317155/
https://ncbi.nlm.nih.gov/pubmed/34337607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacsau.1c00155
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