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Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction
[Image: see text] Although it is well-known that limited local mutations of enzymes, such as matrix metalloproteinases (MMPs), may change enzyme activity by orders of magnitude as well as its stability, the completely rational design of proteins is still challenging. These local changes alter the el...
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| Опубликовано в: : | JACS Au |
|---|---|
| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American
Chemical Society
2021
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8317155/ https://ncbi.nlm.nih.gov/pubmed/34337607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacsau.1c00155 |
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