Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction

[Image: see text] Although it is well-known that limited local mutations of enzymes, such as matrix metalloproteinases (MMPs), may change enzyme activity by orders of magnitude as well as its stability, the completely rational design of proteins is still challenging. These local changes alter the el...

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Bibliographic Details
Published in:JACS Au
Main Authors: Adams, Ellen M., Pezzotti, Simone, Ahlers, Jonas, Rüttermann, Maximilian, Levin, Maxim, Goldenzweig, Adi, Peleg, Yoav, Fleishman, Sarel J., Sagi, Irit, Havenith, Martina
Format: Artigo
Language:Inglês
Published: American Chemical Society 2021
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317155/
https://ncbi.nlm.nih.gov/pubmed/34337607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacsau.1c00155
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