Structure–Activity Relationship of Heterocyclic P2Y(14) Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres

A known zwitterionic, heterocyclic P2Y(14)R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a computational selection process. The most potent analogues contained an uncharged piperidine bioisostere, prescreened in silico, while an...

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Udgivet i:J Med Chem
Main Authors: Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M., Phung, Ngan B., Lieberman, David I., Gopinatth, Varun, Randle, John C. R., Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P., Cook, Donald N., Jacobson, Kenneth A.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317135/
https://ncbi.nlm.nih.gov/pubmed/33787273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00164
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