Structure–Activity Relationship of Heterocyclic P2Y(14) Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres

A known zwitterionic, heterocyclic P2Y(14)R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a computational selection process. The most potent analogues contained an uncharged piperidine bioisostere, prescreened in silico, while an...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Med Chem
Hlavní autoři: Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M., Phung, Ngan B., Lieberman, David I., Gopinatth, Varun, Randle, John C. R., Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P., Cook, Donald N., Jacobson, Kenneth A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317135/
https://ncbi.nlm.nih.gov/pubmed/33787273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00164
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky