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Allele-specific multi-sample copy number segmentation in ASCAT

MOTIVATION: Allele-specific copy number alterations are commonly used to trace the evolution of tumours. A key step of the analysis is to segment genomic data into regions of constant copy number. For precise phylogenetic inference, breakpoints shared between samples need to be aligned to each other...

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Publicat a:Bioinformatics
Autors principals: Ross, Edith M., Haase, Kerstin, Van Loo, Peter, Markowetz, Florian
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317109/
https://ncbi.nlm.nih.gov/pubmed/32449758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa538
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