Laboratory Variants GES(G170L), GES(G170K), and GES(G170H) Increase Carbapenem Hydrolysis and Confer Resistance to Clavulanic Acid

The Guiana extended-spectrum (GES) β-lactamase GES(G170H), GES(G170L), and GES(G170K) mutants showed k(cat), K(m), and k(cat)/K(m) values very dissimilar to those of GES-1 and GES-5. The enhancement of the hydrolytic activity against carbapenems is potentially due to a shift of the substrate in the...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Piccirilli, Alessandra, Mercuri, Paola Sandra, Segatore, Bernardetta, Galleni, Moreno, Brisdelli, Fabrizia, Kerff, Frédéric, Amicosante, Gianfranco, Perilli, Mariagrazia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315993/
https://ncbi.nlm.nih.gov/pubmed/33722888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01931-20
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