Kinetic Studies on CphA Mutants Reveal the Role of the P158-P172 Loop in Activity versus Carbapenems

Site-directed mutagenesis of CphA indicated that prolines in the P158-P172 loop are essential for the stability and the catalytic activity of subclass B2 metallo-β-lactamases against carbapenems. The sequential substitution of proline led to a decrease of the catalytic efficiency of the variant comp...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Bottoni, Carlo, Perilli, Mariagrazia, Marcoccia, Francesca, Piccirilli, Alessandra, Pellegrini, Cristina, Colapietro, Martina, Sabatini, Alessia, Celenza, Giuseppe, Kerff, Frédéric, Amicosante, Gianfranco, Galleni, Moreno, Mercuri, Paola Sandra
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862501/
https://ncbi.nlm.nih.gov/pubmed/26883708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01703-15
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars