Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from Municipal Sewage in Central Italy

Two new natural CphA metallo-β-lactamases, the CphA4 and CphA5 enzymes, were identified in water samples from municipal sewage in central Italy. Compared to CphA, the CphA4 and CphA5 enzymes showed numerous point mutations. These enzymes have a narrow spectrum of substrates focused on carbapenems on...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Bottoni, Carlo, Marcoccia, Francesca, Compagnoni, Chiara, Colapietro, Martina, Sabatini, Alessia, Celenza, Giuseppe, Segatore, Bernardetta, Maturo, Maria Giovanna, Amicosante, Gianfranco, Perilli, Mariagrazia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505251/
https://ncbi.nlm.nih.gov/pubmed/25987617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00628-15
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