Kinetic Studies on CphA Mutants Reveal the Role of the P158-P172 Loop in Activity versus Carbapenems

Site-directed mutagenesis of CphA indicated that prolines in the P158-P172 loop are essential for the stability and the catalytic activity of subclass B2 metallo-β-lactamases against carbapenems. The sequential substitution of proline led to a decrease of the catalytic efficiency of the variant comp...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Bottoni, Carlo, Perilli, Mariagrazia, Marcoccia, Francesca, Piccirilli, Alessandra, Pellegrini, Cristina, Colapietro, Martina, Sabatini, Alessia, Celenza, Giuseppe, Kerff, Frédéric, Amicosante, Gianfranco, Galleni, Moreno, Mercuri, Paola Sandra
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862501/
https://ncbi.nlm.nih.gov/pubmed/26883708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01703-15
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