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Laboratory Variants GES(G170L), GES(G170K), and GES(G170H) Increase Carbapenem Hydrolysis and Confer Resistance to Clavulanic Acid
The Guiana extended-spectrum (GES) β-lactamase GES(G170H), GES(G170L), and GES(G170K) mutants showed k(cat), K(m), and k(cat)/K(m) values very dissimilar to those of GES-1 and GES-5. The enhancement of the hydrolytic activity against carbapenems is potentially due to a shift of the substrate in the...
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| Pubblicato in: | Antimicrob Agents Chemother |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8315993/ https://ncbi.nlm.nih.gov/pubmed/33722888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01931-20 |
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