Mutational Effects on Carbapenem Hydrolysis of YEM-1, a New Subclass B2 Metallo-β-Lactamase from Yersinia mollaretii

Analysis of the genome sequence of Yersinia mollaretii ATCC 43969 identified the bla(YEM) gene, encoding YEM-1, a putative subclass B2 metallo-β-lactamase. The objectives of our work were to produce and purify YEM-1 and to complete its kinetic characterization. YEM-1 displayed the narrowest substrat...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Mercuri, Paola Sandra, Esposito, Roberto, Blétard, Sylvie, Di Costanzo, Stefano, Perilli, Mariagrazia, Kerff, Frédéric, Galleni, Moreno
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449184/
https://ncbi.nlm.nih.gov/pubmed/32540974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00105-20
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