Increased demand for NAD+ relative to ATP drives aerobic glycolysis

Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is associated with proliferation across many organisms and conditions. To better understand this association, we examined the metabolic consequence of activating the pyruvate dehydrogena...

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Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Luengo, Alba, Li, Zhaoqi, Gui, Dan Y., Sullivan, Lucas B., Zagorulya, Maria, Do, Brian T., Ferreira, Raphael, Naamati, Adi, Ali, Ahmed, Lewis, Caroline A., Thomas, Craig J., Spranger, Stefani, Matheson, Nicholas J., Vander Heiden, Matthew G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315838/
https://ncbi.nlm.nih.gov/pubmed/33382985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.012
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