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Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes
Somatic hypermutation (SHM) and class-switch recombination (CSR) of the immunoglobulin (Ig) genes allow B cells to make antibodies that protect us against a wide variety of pathogens. SHM is mediated by activation-induced deaminase (AID), occurs at a million times higher frequency than other mutatio...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8307847/ https://ncbi.nlm.nih.gov/pubmed/34253616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104013118 |
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