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Recombinase-Mediated Cassette Exchange as a Novel Method To Study Somatic Hypermutation in Ramos Cells

Activation-induced cytidine deaminase (AID) mediates the somatic hypermutation (SHM) of immunoglobulin (Ig) variable (V) regions that is required for the generation of antibody diversity and for the affinity maturation of the antibody response against infectious agents and toxic substances. AID pref...

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書誌詳細
主要な著者: Baughn, Linda B., Kalis, Susan L., MacCarthy, Thomas, Wei, Lirong, Fan, Manxia, Bergman, Aviv, Scharff, Matthew D.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Microbiology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190358/
https://ncbi.nlm.nih.gov/pubmed/21990614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00186-11
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