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Recombinase-Mediated Cassette Exchange as a Novel Method To Study Somatic Hypermutation in Ramos Cells

Activation-induced cytidine deaminase (AID) mediates the somatic hypermutation (SHM) of immunoglobulin (Ig) variable (V) regions that is required for the generation of antibody diversity and for the affinity maturation of the antibody response against infectious agents and toxic substances. AID pref...

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Hlavní autoři: Baughn, Linda B., Kalis, Susan L., MacCarthy, Thomas, Wei, Lirong, Fan, Manxia, Bergman, Aviv, Scharff, Matthew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Microbiology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190358/
https://ncbi.nlm.nih.gov/pubmed/21990614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00186-11
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