Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes

Somatic hypermutation (SHM) and class-switch recombination (CSR) of the immunoglobulin (Ig) genes allow B cells to make antibodies that protect us against a wide variety of pathogens. SHM is mediated by activation-induced deaminase (AID), occurs at a million times higher frequency than other mutatio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Duan, Zhi, Baughn, Linda B., Wang, Xiaohua, Zhang, Yongwei, Gupta, Varun, MacCarthy, Thomas, Scharff, Matthew D., Yu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307847/
https://ncbi.nlm.nih.gov/pubmed/34253616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104013118
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