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Direct Synthesis of Enamides via Electrophilic Activation of Amides

[Image: see text] A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scop...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Spieß, Philipp, Berger, Martin, Kaiser, Daniel, Maulide, Nuno
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299460/
https://ncbi.nlm.nih.gov/pubmed/34232035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c04363
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