Chemoselective Alpha‐Deuteration of Amides via Retro‐ene Reaction

A synthetically convenient approach for the direct α‐deuteration of amides is reported. This mechanistically unusual process relies on a retro‐ene‐type process, triggered by the addition of deuterated dimethyl sulfoxide to a keteniminium intermediate, generated through electrophilic amide activation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chemistry
Egile Nagusiak: Porte, Vincent, Di Mauro, Giovanni, Schupp, Manuel, Kaiser, Daniel, Maulide, Nuno
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2020
Gaiak:
Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756638/
https://ncbi.nlm.nih.gov/pubmed/33035360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202004103
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