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Chemoselective α,β‐Dehydrogenation of Saturated Amides

We report a method for the selective α,β‐dehydrogenation of amides in the presence of other carbonyl moieties under mild conditions. Our strategy relies on electrophilic activation coupled to in situ selective selenium‐mediated dehydrogenation. The α,β‐unsaturated products were obtained in moderate...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Teskey, Christopher J., Adler, Pauline, Gonçalves, Carlos R., Maulide, Nuno
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348382/
https://ncbi.nlm.nih.gov/pubmed/30332524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201808794
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