Unified Approach to the Chemoselective α-Functionalization of Amides with Heteroatom Nucleophiles

[Image: see text] Functionalization at the α-position of carbonyl compounds has classically relied on enolate chemistry. As a result, the generation of a new C–X bond, where X is more electronegative than carbon requires an oxidation event. Herein we show that, by rendering the α-position of amides...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Gonçalves, Carlos R., Lemmerer, Miran, Teskey, Christopher J., Adler, Pauline, Kaiser, Daniel, Maryasin, Boris, González, Leticia, Maulide, Nuno
Format: Artigo
Language:Inglês
Published: American Chemical Society 2019
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879173/
https://ncbi.nlm.nih.gov/pubmed/31714077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06956
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