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Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization

[Image: see text] Herein, we report a metal-free synthesis of cyclic amidines, oxazines, and an oxazinone under mild conditions by electrophilic amide activation. This strategy features an unusual Umpolung cyclization mode and enables the smooth union of α-aryl amides and diverse alkylazides, effect...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Zhang, Haoqi, Riomet, Margaux, Roller, Alexander, Maulide, Nuno
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7091535/
https://ncbi.nlm.nih.gov/pubmed/32159354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c00571
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