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Enantioselective Synthesis of α-Oxy Amides via Umpolung Amide Synthesis

α-Oxy amides are prepared through enantioselective synthesis using a sequence beginning with a Henry addition of bromonitromethane to aldehydes, and finishing with Umpolung Amide Synthesis (UmAS). Key to high enantioselection is the finding that ortho-iodo benzoic acid salts of the chiral copper(II)...

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Detalhes bibliográficos
Main Authors: Leighty, Matthew W., Shen, Bo, Johnston, Jeffrey N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477818/
https://ncbi.nlm.nih.gov/pubmed/22967461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja306225u
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