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The inverted ketene synthon: a double umpolung approach to enantioselective β(2,3)-amino amide synthesis

A stereocontrolled synthesis of β(2,3)-amino amides is reported. Innovation is encapsulated by the first use of nitroalkenes to achieve double umpolung in enantioselective β-amino amide synthesis. Step economy is also fulfilled by the use of Umpolung Amide Synthesis (UmAS) in the second step, delive...

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Publicado en:Chem Sci
Autores principales: Vishe, Mahesh, Johnston, Jeffrey N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349014/
https://ncbi.nlm.nih.gov/pubmed/30774911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc04330b
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