New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids

5-Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the small and large intestine of patients. Symptoms can be severe and lead to the interruption of cancer treatments. However, there is limited understanding of the molecular mechanisms underlying 5-FU-induced in...

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Dettagli Bibliografici
Pubblicato in:Arch Toxicol
Autori principali: Rodrigues, Daniela, de Souza, Terezinha, Coyle, Luke, Di Piazza, Matteo, Herpers, Bram, Ferreira, Sofia, Zhang, Mian, Vappiani, Johanna, Sévin, Daniel C., Gabor, Attila, Lynch, Anthony, Chung, Seung-Wook, Saez-Rodriguez, Julio, Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2021
Soggetti:
Toxicogenomics and Omics Technologies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298376/
https://ncbi.nlm.nih.gov/pubmed/34151400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-03092-2
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