New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids

5-Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the small and large intestine of patients. Symptoms can be severe and lead to the interruption of cancer treatments. However, there is limited understanding of the molecular mechanisms underlying 5-FU-induced in...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Rodrigues, Daniela, de Souza, Terezinha, Coyle, Luke, Di Piazza, Matteo, Herpers, Bram, Ferreira, Sofia, Zhang, Mian, Vappiani, Johanna, Sévin, Daniel C., Gabor, Attila, Lynch, Anthony, Chung, Seung-Wook, Saez-Rodriguez, Julio, Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
Assuntos:
Toxicogenomics and Omics Technologies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298376/
https://ncbi.nlm.nih.gov/pubmed/34151400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-03092-2
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