Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells

Metabolic dysregulation underlies malignant phenotypes attributed to cancer stem cells, such as unlimited proliferation and differentiation blockade. Here, we demonstrate that NAD(+) metabolism enables acute myeloid leukemia (AML) to evade apoptosis, another hallmark of cancer stem cells. We integra...

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Bibliografische gegevens
Gepubliceerd in:Sci Adv
Hoofdauteurs: Shi, Xiangguo, Jiang, Yajian, Kitano, Ayumi, Hu, Tianyuan, Murdaugh, Rebecca L., Li, Yuan, Hoegenauer, Kevin A., Chen, Rui, Takahashi, Koichi, Nakada, Daisuke
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2021
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294764/
https://ncbi.nlm.nih.gov/pubmed/34290089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf3895
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