Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells

Metabolic dysregulation underlies malignant phenotypes attributed to cancer stem cells, such as unlimited proliferation and differentiation blockade. Here, we demonstrate that NAD(+) metabolism enables acute myeloid leukemia (AML) to evade apoptosis, another hallmark of cancer stem cells. We integra...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Shi, Xiangguo, Jiang, Yajian, Kitano, Ayumi, Hu, Tianyuan, Murdaugh, Rebecca L., Li, Yuan, Hoegenauer, Kevin A., Chen, Rui, Takahashi, Koichi, Nakada, Daisuke
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294764/
https://ncbi.nlm.nih.gov/pubmed/34290089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf3895
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