Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells

Metabolic dysregulation underlies malignant phenotypes attributed to cancer stem cells, such as unlimited proliferation and differentiation blockade. Here, we demonstrate that NAD(+) metabolism enables acute myeloid leukemia (AML) to evade apoptosis, another hallmark of cancer stem cells. We integra...

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Detaylı Bibliyografya
Yayımlandı:Sci Adv
Asıl Yazarlar: Shi, Xiangguo, Jiang, Yajian, Kitano, Ayumi, Hu, Tianyuan, Murdaugh, Rebecca L., Li, Yuan, Hoegenauer, Kevin A., Chen, Rui, Takahashi, Koichi, Nakada, Daisuke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2021
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294764/
https://ncbi.nlm.nih.gov/pubmed/34290089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf3895
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