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AMPK protects leukemia-initiating cells in myeloid leukemias from metabolic stress in the bone marrow
How cancer cells adapt to metabolically adverse conditions in patients and strive to proliferate is a fundamental question in cancer biology. Here we show that AMP-activated protein kinase (AMPK), a metabolic checkpoint kinase, confers metabolic stress resistance to leukemia-initiating cells (LICs)...
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| Publicado no: | Cell Stem Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4597792/ https://ncbi.nlm.nih.gov/pubmed/26440282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.08.019 |
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