PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cells

Oncogenic mutations confer on cells the ability to propagate indefinitely, but whether oncogenes alter the cell fate of these cells is unknown. Here, we show that the transcriptional regulator PRDM16s causes oncogenic fate conversion by transforming cells fated to form platelets and erythrocytes int...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Hu, Tianyuan, Morita, Kiyomi, Hill, Matthew C., Jiang, Yajian, Kitano, Ayumi, Saito, Yusuke, Wang, Feng, Mao, Xizeng, Hoegenauer, Kevin A., Morishita, Kazuhiro, Martin, James F., Futreal, P. Andrew, Takahashi, Koichi, Nakada, Daisuke
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695560/
https://ncbi.nlm.nih.gov/pubmed/31270104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018888255
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi