PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cells

Oncogenic mutations confer on cells the ability to propagate indefinitely, but whether oncogenes alter the cell fate of these cells is unknown. Here, we show that the transcriptional regulator PRDM16s causes oncogenic fate conversion by transforming cells fated to form platelets and erythrocytes int...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Hu, Tianyuan, Morita, Kiyomi, Hill, Matthew C., Jiang, Yajian, Kitano, Ayumi, Saito, Yusuke, Wang, Feng, Mao, Xizeng, Hoegenauer, Kevin A., Morishita, Kazuhiro, Martin, James F., Futreal, P. Andrew, Takahashi, Koichi, Nakada, Daisuke
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695560/
https://ncbi.nlm.nih.gov/pubmed/31270104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018888255
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