AMPK protects leukemia-initiating cells in myeloid leukemias from metabolic stress in the bone marrow

How cancer cells adapt to metabolically adverse conditions in patients and strive to proliferate is a fundamental question in cancer biology. Here we show that AMP-activated protein kinase (AMPK), a metabolic checkpoint kinase, confers metabolic stress resistance to leukemia-initiating cells (LICs)...

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Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Saito, Yusuke, Chapple, Richard H., Lin, Angelique, Kitano, Ayumi, Nakada, Daisuke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597792/
https://ncbi.nlm.nih.gov/pubmed/26440282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.08.019
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