Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells

Metabolic dysregulation underlies malignant phenotypes attributed to cancer stem cells, such as unlimited proliferation and differentiation blockade. Here, we demonstrate that NAD(+) metabolism enables acute myeloid leukemia (AML) to evade apoptosis, another hallmark of cancer stem cells. We integra...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Adv
मुख्य लेखकों: Shi, Xiangguo, Jiang, Yajian, Kitano, Ayumi, Hu, Tianyuan, Murdaugh, Rebecca L., Li, Yuan, Hoegenauer, Kevin A., Chen, Rui, Takahashi, Koichi, Nakada, Daisuke
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Association for the Advancement of Science 2021
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294764/
https://ncbi.nlm.nih.gov/pubmed/34290089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf3895
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