Gating movements and ion permeation in HCN4 pacemaker channels

The HCN1–4 channel family is responsible for the hyperpolarization-activated cation current I(f)/I(h) that controls automaticity in cardiac and neuronal pacemaker cells. We present cryoelectron microscopy (cryo-EM) structures of HCN4 in the presence or absence of bound cAMP, displaying the pore doma...

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Udgivet i:Mol Cell
Main Authors: Saponaro, Andrea, Bauer, Daniel, Giese, M. Hunter, Swuec, Paolo, Porro, Alessandro, Gasparri, Federica, Sharifzadeh, Atiyeh Sadat, Chaves-Sanjuan, Antonio, Alberio, Laura, Parisi, Giacomo, Cerutti, Gabriele, Clarke, Oliver B., Hamacher, Kay, Colecraft, Henry M., Mancia, Filippo, Hendrickson, Wayne A., Siegelbaum, Steven A., DiFrancesco, Dario, Bolognesi, Martino, Thiel, Gerhard, Santoro, Bina, Moroni, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294335/
https://ncbi.nlm.nih.gov/pubmed/34166608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.05.033
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