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cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4

Direct regulation of the pacemaker “funny” current (I(f)) by cyclic AMP (cAMP) underlies heart rate modulation by the autonomic nervous system. At the molecular level, cAMP activates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that drive I(f) in sinoatrial node (SAN) myocytes....

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Publicado en:Front Physiol
Autores principales: Porro, Alessandro, Thiel, Gerhard, Moroni, Anna, Saponaro, Andrea
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358946/
https://ncbi.nlm.nih.gov/pubmed/32733276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00771
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