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cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4

Direct regulation of the pacemaker “funny” current (I(f)) by cyclic AMP (cAMP) underlies heart rate modulation by the autonomic nervous system. At the molecular level, cAMP activates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that drive I(f) in sinoatrial node (SAN) myocytes....

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Bibliografske podrobnosti
izdano v:Front Physiol
Main Authors: Porro, Alessandro, Thiel, Gerhard, Moroni, Anna, Saponaro, Andrea
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358946/
https://ncbi.nlm.nih.gov/pubmed/32733276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00771
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