Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP

Important targets for cAMP signalling in the heart are hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels that underlie the depolarizing ‘pacemaker' current, I(f). We studied the role of I(f) in mice, in which binding of cAMP to HCN4 channels was abolished by a single amino-...

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Detalhes bibliográficos
Main Authors: Harzheim, Dagmar, Pfeiffer, K Holger, Fabritz, Larissa, Kremmer, Elisabeth, Buch, Thorsten, Waisman, Ari, Kirchhof, Paulus, Kaupp, U Benjamin, Seifert, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2262033/
https://ncbi.nlm.nih.gov/pubmed/18219271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.3
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