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Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide

Members of the HCN channel family generate hyperpolarization-activated cation currents (I(h)) that are directly regulated by cAMP and contribute to pacemaker activity in heart and brain. The four HCN isoforms show distinct but overlapping patterns of expression in different tissues. Here, we report...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Shan, Wang, Jing, Siegelbaum, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233656/
https://ncbi.nlm.nih.gov/pubmed/11331358
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