Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide

Members of the HCN channel family generate hyperpolarization-activated cation currents (I(h)) that are directly regulated by cAMP and contribute to pacemaker activity in heart and brain. The four HCN isoforms show distinct but overlapping patterns of expression in different tissues. Here, we report...

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Bibliographic Details
Main Authors: Chen, Shan, Wang, Jing, Siegelbaum, Steven A.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233656/
https://ncbi.nlm.nih.gov/pubmed/11331358
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