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A reduced mechanical model for cAMP-modulated gating in HCN channels
We developed an in silico mechanical model to analyze the process of cAMP-induced conformational modulations in hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which conduct cations across the membrane of mammalian heart and brain cells. The structural analysis reveals a quaterna...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5225470/ https://ncbi.nlm.nih.gov/pubmed/28074902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40168 |
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