A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Binding of TRIP8b to the cyclic nucleotide binding domain (CNBD) of mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels prevents their regulation by cAMP. Since TRIP8b is expressed exclusively in the brain, we envisage that it can be used for orthogonal control of HCN channe...

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Bibliographic Details
Published in:eLife
Main Authors: Saponaro, Andrea, Cantini, Francesca, Porro, Alessandro, Bucchi, Annalisa, DiFrancesco, Dario, Maione, Vincenzo, Donadoni, Chiara, Introini, Bianca, Mesirca, Pietro, Mangoni, Matteo E, Thiel, Gerhard, Banci, Lucia, Santoro, Bina, Moroni, Anna
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Structural Biology and Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023613/
https://ncbi.nlm.nih.gov/pubmed/29923826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35753
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