Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function

cAMP signaling in the brain mediates several higher order neural processes. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels directly bind cAMP through their cytoplasmic cyclic nucleotide binding domain (CNBD), thus playing a unique role in brain function. Neuronal HCN channels are...

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Detalhes bibliográficos
Main Authors: Saponaro, Andrea, Pauleta, Sofia R., Cantini, Francesca, Matzapetakis, Manolis, Hammann, Christian, Donadoni, Chiara, Hu, Lei, Thiel, Gerhard, Banci, Lucia, Santoro, Bina, Moroni, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210022/
https://ncbi.nlm.nih.gov/pubmed/25197093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410389111
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