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Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function
cAMP signaling in the brain mediates several higher order neural processes. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels directly bind cAMP through their cytoplasmic cyclic nucleotide binding domain (CNBD), thus playing a unique role in brain function. Neuronal HCN channels are...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210022/ https://ncbi.nlm.nih.gov/pubmed/25197093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410389111 |
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