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Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP

Hyperpolarization-activated cyclic nucleotide–regulated cation (HCN) channels generate the hyperpolarization-activated cation current Ih present in many neurons. These channels are directly regulated by the binding of cAMP, which both shifts the voltage dependence of HCN channel opening to more posi...

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Autors principals: Hu, Lei, Santoro, Bina, Saponaro, Andrea, Liu, Haiying, Moroni, Anna, Siegelbaum, Steven
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840918/
https://ncbi.nlm.nih.gov/pubmed/24277603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311013
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