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The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are major regulators of synaptic plasticity and rhythmic activity in the heart and brain. Opening of HCN channels requires membrane hyperpolarization and is further facilitated by intracellular cyclic nucleotides (cNMPs). In HCN chan...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7294080/ https://ncbi.nlm.nih.gov/pubmed/32341127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013281 |
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