The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are major regulators of synaptic plasticity and rhythmic activity in the heart and brain. Opening of HCN channels requires membrane hyperpolarization and is further facilitated by intracellular cyclic nucleotides (cNMPs). In HCN chan...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Wang, Ze-Jun, Blanco, Ismary, Hayoz, Sebastien, Brelidze, Tinatin I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2020
Konular:
Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294080/
https://ncbi.nlm.nih.gov/pubmed/32341127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013281
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